ERA-EDTA Operative Headquarters
Via XXIV Maggio 38
43123 Parma – Italy
Phone: +39 0521 989078
Fax: +39 0521 959242
E-mail: secretariat@era-edta.org
ERA-EDTA Registered Office
c/o PKF Littlejohn, 15 Westferry Circus, Canary Wharf
London E14 4HD – United Kingdom
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PR3-ANCAs predict relapses in ANCA-associated vasculitis patients after rituximab treatment
News, News-HomeRituximab (RTX) is an effective remission-induction and maintenance treatment for patients with anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV). The major challenge of patient care is the early detection of relapse to prevent organ damage and improve survival in these individuals. A recently published single-center cohort study assessed serial ANCA, CD19+ B-cell status and relapse rate […]
Acute PD in the treatment of COVID-19-related AKI
News, News-HomeAcute kidney injury (AKI) may occur in 4-23% of patients with COVID-19. Those who require renal replacement therapy have mainly been treated with extracorporeal dialysis. However, peritoneal dialysis (PD) may also be considered as a valuable treatment option in such cases when there is a capacity limit or availability constraint of equipment and supplies for […]
Easy estimation of renal growth rate in ADPKD
News, News-HomeAutosomal dominant polycystic kidney disease (ADPKD) is characterized by the exponential and unlimited enlargement of the total kidney volume (TKV) associated with a decrease in renal function. In the prospective, placebo-controlled tolvaptan efficacy and safety in the management of ADPKD and its outcomes (TEMPO) 3:4 trial a mixed-model repeated-measures analysis was applied to assess a […]
Are those really SARS-CoV-2 virions in the kidney?
News, News-HomeSeveral studies report direct infection of different types of kidney cells by SARS-CoV-2 detected by transmission electron microscopy (TEM) both on post-mortem analysis and kidney biopsy specimens. However, these studies did not include detection of viral RNA or other methods for viral detection of kidney specimens and thus it is unclear whether the observed particles […]
Is longer dialysis necessarily better? The results of the ACTIVE Trial
News, News-HomeA Clinical Trial of IntensiVE (ACTIVE) Dialysis randomized 200 participants to extended hours (≥24 hours/week) or standard (≤18 hours/week) dialysis for 12 months to determine whether extended hours result in improved survival. After completing the 12-month study period participants could change their dialysis regimen, but continued a pre-specified observational follow-up for a further 4 years. […]
Elbasvir and grazoprevir successfully eliminate HCV infection in HCV-naïve recipients of HCV-infected kidneys
News, News-HomeHCV infected persons represent a growing pool of organ donors because they are typically younger and have fewer comorbidities than average donors. The introduction of direct-acting antivirals (DAAs) which successfully achieve sustained virologic response in >95% of cases has opened the door to clinical trials investigating feasibility and safety of transplantations from HCV-infected donors to […]
Cardiovascular risk of nonsteroidal anti-inflammatory drugs occurs independently of dose and duration of exposure in dialysis patients
News, News-HomeNonsteroidal anti-inflammatory drugs (NSAIDs) are commonly prescribed in dialysis patients, despite their well-established adverse effects. A case cross-over study was conducted by Joo et al. to assess the association of NSAIDs with major adverse cardiac and cerebrovascular events (MACCEs) and mortality in dialysis patients. The results showed that nonselective NSAIDs significantly increased the risk of […]
Dysregulated turnover of collagen type III is an important determinant of chronic kidney disease progression
News, News-HomeCollagen type III (COL3) is one of the most abundant extracellular matrix components in the human body; decreased urinary levels of a degradation fragment of COL3 (C3M) were associated with the severity of CKD in patients with immunoglobulin A nephropathy and kidney allograft failure. Genovese et al. assessed the relationship between fragments reflecting active formation […]
Elderly patients also benefit from kidney transplantation
News, News-HomeSo far, kidney transplantation has generally not been offered to elderly patients (>75 years) because of the perioperative risks. Nor has it been clearly established whether transplanted patients in this age benefit significantly. In a new study published in NDT, the graft survival proved to be excellent, and nearly all patients remained dialysis-free. Is it […]
Consensus statement from the American College of Radiology and the National Kidney Foundation on the use of intravenous iodinated contrast media in patients with kidney disease
News, News-HomeThe true risk of contrast induced acute kidney injury is unknown. However, the presumed risk of administering modern intravenous iodinated contrast media in patients with reduced kidney function seems to be overstated. A recently disclosed consensus statement from the American College of Radiology and the National Kidney Foundation define the patients at high risk to […]