EUDIAL actively contributed in the creation of the special web page pertaining to global outbreak of COVID-19
NEW Video and publication in NDT!
Watch the video At least 156 reasons to prioritize COVID-19 vaccination in patients receiving in-centre haemodialysis presented by Alexander H. Kirsch and read the full paper.
MISSION
The Council of the European Renal Association-European Dialysis Transplant Association (ERA-EDTA) has officially approved the creation of a Working Group aimed at encouraging research, communicating knowledge, teaching and contributing to education in the field of haemodialysis. The acronym EUDIAL, standing for European Dialysis Working Group, has been chosen to best summarize its activity and mission. The vision and mission of this Working Group as formulated by the ERA-EDTA are clearly identified to improve outcomes of chronic kidney disease patients by enhancing the quality of dialysis therapies in their broader sense and facilitating collaborative research in this field.
Given the increasing scientific interest in convective therapies (hemodiafiltration and hemofiltration), the working group has decided to focusing on convective renal replacement therapies as the first aim. The rationale of this first mission is supported by several facts that include an increasing interest in convective therapies translating in a rapid growth of patients treated by modern versions of these therapies and several reports suggesting an improvement in CKD patient outcomes.
In addition, the European nephrology community has been leading in this field of renal replacement therapy for more than two decades. The concept of ultrapure dialysis fluid introduced in 1987 is now accepted as a standard for all dialysis forms. The European notified bodies have certified water treatment systems and hemodialysis machines for online production of substitution fluid. The European scientific community has launched the first randomized controlled trials comparing outcomes of CKD patients treated either by hemodiafiltration/hemofiltration or conventional hemodialysis. The highest prevalence of CKD patients treated by hemodiafiltration is found in Europe and it is increasing regularly over the time.
BOARD
Carlo Basile (Italy) – Chair
Sandip Mitra (United Kingdom) – Vice Chair
Christian Combe (France)
Adrian Covic (Romania)
Mehmet Kanbay (Turkey)
Dimitri Kirmizis (United Kingdom)
Vassilios Liakopoulos (Greece)
Valerie Luyckx (Switzerland)
Rukshana Shroff (United Kingdom)
Frank van der Sande (Netherlands)
HOW TO JOIN THE WORKING GROUP
Being a ordinary member of the EUDIAL means being part of a network which facilitates exchanges of ideas on basic science research and new treatment protocols.
Becoming an ordinary member of the EUDIAL is FREE OF CHARGE (ERA-EDTA Membership is not mandatory) and is also open to non-nephrologists.
By joining the EUDIAL you will receive constant updates on the Working Group initiatives be included in the Directory of EUDIAL’ ordinary members and start networking with colleagues from all over the world.
Click here to join.
The ordinary membership application is subject to validation. Please allow some time for a quick administrative check before applying multiple times.
PUBLICATIONS
At least 156 reasons to prioritize COVID-19 vaccination in patients receiving in-centre haemodialysis
Nephrology Dialysis Transplantation, January 2021 – Editorial
Click here to watch the video
The reasons for a clinical trial on incremental haemodialysis
Nephrology Dialysis Transplantation, October 2020
Click here to watch the video
Coronary Artery Disease in Dialysis Patients: Evidence Synthesis, Controversies and Proposed Management Strategies
Journal of Nephrology, May 2020
Recommendations for the prevention, mitigation and containment of the emerging SARS-CoV-2 (COVID-19) pandemic in haemodialysis centres
Nephrology Dialysis Transplantation, March 2020
Sudden cardiac death in dialysis patients: different causes and management strategies
Nephrology Dialysis Transplantation, September 2019
Pros and cons of antithrombotic therapy in end-stage kidney disease: a 2019 update
Nephrology Dialysis Transplantation, March 2019
Incremental haemodialysis and residual kidney function: more and more observations but no trials
Nephrology Dialysis Transplantation, February 2019
Should a fistula first policy be revisited in elderly haemodialysis patients?
Nephrology Dialysis Transplantation, October 2018
HDF Pooling Project investigators. The importance of considering competing treatment affecting prognosis in the evaluation of therapy in trials: the example of renal transplantation in hemodialysis trials.
Nephrology Dialysis Transplantation, February 2017
HDF Pooling Project investigators. Mortality reduction by post-dilution online-haemodiafiltration: a cause-specific analysis.
Nephrology Dialysis Transplantation, December 2016
Why choose high volume online post-dilution hemodiafiltration?
Journal of Nephrology, September 2016
Reconciling and Closing the Loop Between Evidence-Based and Practice-Based Medicine: The Case for Hemodiafiltration.
Am J Kidney Dis., August 2016
Changes in Cardiac Output and Perfusion during Hemodialysis and Hemodiafiltration Treatments Determined by Cardiac Magnetic Resonance Imaging.
J Am Soc Nephrol. April 2017
Are There Any Downsides, Barriers, or Challenges in Delivering Hemodiafiltration in Everyday Clinical Practice?
Contrib Nephrol. 2017;
HDF Pooling Project Investigators. Haemodiafiltration and mortality in end-stage kidney disease patients: a pooled individual participant data analysis from four randomized controlled trials.
Nephrology Dialysis Transplantation,. June 2016
HDF Pooling Project Investigators. Higher convection volume exchange with online hemodiafiltration is associated with survival advantage for dialysis patients: the effect of adjustment for body size.
Kidney International, January 2016
ONGOING PROJECTS
- Randomized controlled trial (RCT) on incremental haemodialysis – There is growing interest in an incremental approach to haemodialysis for incident end-stage kidney disease patients, starting with one or two sessions per week. Such an approach not only seems to preserve residual kidney function (RKF) and improve health-related quality of life with similar survival rates than those observed in patients receiving the standard thrice-weekly haemodialysis regimen, but also allows saving economic resources.
The term “incremental haemodialysis” means that, in the presence of substantial RKF, both dialysis dose and frequency can be low at dialysis inception but should be progressively increased, to compensate for any subsequent reduction in RKF.
At the present time no randomized clinical trial (RCT) testing incremental haemodialysis has yet been published. To this end, the EUDIAL Working Group is starting the “RandomizEd clinicAL triaL on the effIcacy and saFety of incremental haEmodialysis” (REAL LIFE). It is a pragmatic, prospective, multicentre, open label RCT, investigator-initiated, comparing the intervention arm (incremental haemodialysis) with the control arm (standard thrice-weekly haemodialysis).
A research letter dealing with the RCT has been recently published: The reasons for a clinical trial on incremental haemodialysis. NDT, October 2020. A video is accompanying the paper. A dedicated website has been built-up: www.incrementaldialysis.eu
European dialysis centres are warmly invited to join.
- The CONVINCE study, a European prospective randomised controlled trial comparing high-volume on-line haemodiafiltration and high-flux haemodialysis, sponsored by European Union’s Horizon 2020 research and innovation programme (grant agreement No 754803), has now recruited more than 500 patients from dialysis centres spread across Europe from Portugal to Romania. This trial is designed to compare all-cause mortality, cause specific mortality, hospitalisations, quality of life and health care costs between modalities (www.convincetrial.eu).
- EUDIAL Pooling project of trials in HDF (ongoing) a meta-analysis of the individual patient data from the 4 prospective trials of haemodiafiltration compared to haemodialysis.
PAST EVENTS
‘Haemodialysis Update 2018: from basics to advances in the treatment of CKD‘ was held at the Annual Meeting of the Italian Society of Nephrology (Società Italiana di Nefrologia – SIN), in Rimini (Italy) on October 3, 2018.
Contacts
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