Author Archive for: ERA-EDTA

Entries by ERA-EDTA

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Elbasvir and grazoprevir successfully eliminate HCV infection in HCV-naïve recipients of HCV-infected kidneys

HCV infected persons represent a growing pool of organ donors because they are typically younger and have fewer comorbidities than average donors. The introduction of direct-acting antivirals (DAAs) which successfully achieve sustained virologic response in >95% of cases has opened the door to clinical trials investigating feasibility and safety of transplantations from HCV-infected donors to […]

3 March 2020 by
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Cardiovascular risk of nonsteroidal anti-inflammatory drugs occurs independently of dose and duration of exposure in dialysis patients

Nonsteroidal anti-inflammatory drugs (NSAIDs) are commonly prescribed in dialysis patients, despite their well-established adverse effects. A case cross-over study was conducted by Joo et al. to assess the association of NSAIDs with major adverse cardiac and cerebrovascular events (MACCEs) and mortality in dialysis patients. The results showed that nonselective NSAIDs significantly increased the risk of […]

28 February 2020 by
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Dysregulated turnover of collagen type III is an important determinant of chronic kidney disease progression

Collagen type III (COL3) is one of the most abundant extracellular matrix components in the human body; decreased urinary levels of a degradation fragment of COL3 (C3M) were associated with the severity of CKD in patients with immunoglobulin A nephropathy and kidney allograft failure. Genovese et al. assessed the relationship between fragments reflecting active formation […]

27 February 2020 by
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Elderly patients also benefit from kidney transplantation

So far, kidney transplantation has generally not been offered to elderly patients (>75 years) because of the perioperative risks. Nor has it been clearly established whether transplanted patients in this age benefit significantly. In a new study published in NDT, the graft survival proved to be excellent, and nearly all patients remained dialysis-free. Is it […]

26 February 2020 by
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Consensus statement from the American College of Radiology and the National Kidney Foundation on the use of intravenous iodinated contrast media in patients with kidney disease

The true risk of contrast induced acute kidney injury is unknown. However, the presumed risk of administering modern intravenous iodinated contrast media in patients with reduced kidney function seems to be overstated. A recently disclosed consensus statement from the American College of Radiology and the National Kidney Foundation define the patients at high risk to […]

21 February 2020 by
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Simultaneous pancreas-kidney (SPK) transplantation improves survival compared with kidney transplantation alone in patients with diabetes type 1

Patients with type 1 diabetes and end-stage kidney disease experience inferior survival on dialysis and benefit most from a pre-emptive kidney transplantation. A nationwide study conducted in the Netherlands included 2,796 patients with type 1 diabetes who started renal replacement therapy between 1986 and 2016 and compared long-term survival in those who received a SPK […]

20 February 2020 by
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Aetiology and management of acute interstitial nephritis

Acute interstitial nephritis (AIN) may be a contributory factor in up to 35% of cases of acute kidney injury. The typical histological lesion is infiltration of the interstitial renal tissue by inflammatory cells. AIN can complicate a variety of diseases, including autoimmune conditions (Sjögren’s syndrome, inflammatory bowel diseases, primary biliary cholangitis and sarcoidosis), infections, oxalosis, […]

19 February 2020 by
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Serum bicarbonate as a cardiovascular risk factor

Cardiovascular disease (CVD) remains the leading cause of death in chronic kidney disease (CKD) patients. Metabolic acidosis is a risk factor for CVD and increases overall mortality risk in CKD patients, but also in the general population. An editorial by D. E. Wesson in Nephrology Dialysis Transplantation (NDT) explores available evidence on the mechanisms through […]

18 February 2020 by
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Urinary epidermal growth factor (uEGF) is a potential novel biomarker of kidney function in children with nephrotic syndrome

Urinary EGF has recently emerged as a highly promising biomarker of chronic kidney disease (CKD) progression. In recently published research, Gipson et al. investigated the possible predictive role of uEGF in the pediatric nephrotic syndrome population. The study evaluated 191 participants with nephrotic syndrome; EGF/creatinine was measured in urine and renal EGF mRNA was determined […]

17 February 2020 by
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Podocytes become sensitized to angiotensin II-induced calcium signaling upon injury

Inhibition of angiotensin II (AngII) signaling is the cornerstone of management of proteinuric kidney disease. However, the relevance of AngII signaling in podocytes has thus been poorly investigated. In a recent study on mouse models, podocytes displayed limited responsiveness to AngII stimulation in healthy animals. On the other hand, proteinuric animals exhibited a notable podocyte […]

13 February 2020 by

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