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The complement system is a critical modulator of the immune response. When disrupted, it can attack host cells and contribute to inflammatory conditions. The new insights into complement cascade activation mechanisms suggest that these proteins have more diverse roles and can cause more damage than previously thought. Many diseases are associated with complement activation including stroke, Alzheimer’s disease, age-related macular degeneration, asthma, myocardial infarction, Crohn’s disease, rheumatoid arthritis, membranous nephropathy, IgA nephropathy, systemic lupus erythematosus, ANCA vasculitis, etc.
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