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NDT-Educational Newsletter
Issue 19 - February 2020
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EDITOR IN CHIEF: Davide Bolignano
EDITORIAL BOARD: click here for the complete list
NEWSLETTER DESIGN: Francesca Trebelli
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Summary Reports from 56th ERA-EDTA Congress
New therapeutic targets in Alport syndrome
Presented by Roser Torra
Alport syndrome (AS) is a progressive hereditary renal disease accompanied by sensorineural hearing loss and ocular abnormalities. AS develops because of pathogenic variants in the COL4A3, COL4A4, and COL4A5 genes encoding type IV collagen α3, α4, and α5 chains that constitute the glomerular basement membrane (GBM). It is divided into three modes of inheritance, namely, X-linked Alport syndrome (XLAS), autosomal recessive AS (ARAS), and autosomal dominant AS (ADAS). XLAS is caused by pathogenic variants in COL4A5, while ADAS and ARAS are caused by those in COL4A3/COL4A4.
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Congress Presentation
This talk has been presented by Roser Torra during the 56th ERA-EDTA Congress in Budapest, Hungary.
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Phosphate toxicity in the kidney
Presented by Carsten Wagner
Phosphorus is an essential nutrient for human health that has a variety of physiological roles mostly in the form of inorganic phosphate. These include structural roles, as phosphate is a major component of cell membranes (i.e. phospholipid bilayer), the sugar-phosphate backbone of nucleic acids, and in the form of hydroxyapatite it is essential in bones and teeth. Additionally, phosphate plays important roles in energy metabolism (e.g. in ATP, GTP, ADP, GDP), in acid/base balance, and in intracellular cell signalling. During evolution, our food always contained small amounts of phosphate. Thus, our body has evolved to absorb phosphate very efficiently from food and to hold on to it by reabsorbing as much as needed from urine.
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Congress Presentation
This talk has been presented by Carsten Wagner during the 56th ERA-EDTA Congress in Budapest, Hungary.
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References
Read this selection of articles about the two summary report fields.
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ERA-EDTA Twitter Dialogues
A hot off the press meta-analysis in JACC about oral anticoagulation for long term dialysis patients with non-valvular atrial fibrillation.Apixaban 5mg twice daily lowered mortality risk vs warfarin or no anticoagulation as well as bleeding risk vs other NOACs and warfarin. Is it time to change our practice?
By Evangelia Ntounousi
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Omics technologies have revolutionized kidney research and much can be done to identify non-invasive biomarkers with these approaches. Metabolomics has seen alternate fortune but has great potential as evidence accumulates. Which fluid would you use as source for Metabolomics biomarkers discovery and in which pathological setting do you think the most urgent need is?
By Francesco Pesce
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Are you an ERA-EDTA active Member with an interesting case to be discussed? Suggest a new ERA-EDTA Dialogue, if accepted it will be published on Twitter and on NDT-Educational website!
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