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FOR KIDNEY & BLOOD
PRESSURE RELATED
DISORDERS
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An official publication of
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NDT-Educational@ENP Newsletter
Issue 3 - March 2019
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EDITOR IN CHIEF: Davide Bolignano
EDITORIAL BOARD: click here for the complete list
NEWSLETTER DESIGN: Francesca Trebelli
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Summary Reports from 55th ERA-EDTA Congress
Inflammation in crystal nephropathies
Presented by Hans-Joachim Anders
Deposits of crystals, misfolded proteins, or airborne nanoparticles or microparticles can cause diverse acute or chronic organ injuries. Crystal-associated diseases, although with diverse clinical presentations, share several molecular and cellular pathomechanisms, and are usually referred to as the ‘crystallopathies’.
According to their predominant pathologic mechanism, Mulay and Anders suggested a classification of crystal-related or microparticle-related disorders in the three categories: 1) acute necroinflammation, 2) chronic tissue remodeling leading to tissue atrophy and scarring, and 3) obstruction of ducts, cavities, or vessels by large crystal masses, calculi, or stones.
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Congress Presentation
This Congress talk has been presented by Hans-Joachim Anders during the 55th ERA-EDTA Congress in Copenhagen, Denmark.
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Klotho and endocrine FGFs – marker of CKD progression and cardiovascular complications?
Presented by Makoto Kuro-o
Klotho, the Greek goddess who spins the thread of life, has become popular among nephrologists, as the genes named after her encode co-receptors for hormones that play critical roles in the pathophysiology of chronic kidney disease (CKD).
The Klotho gene was discovered in 1997 when mice with serendipitous silencing of this gene developed premature ageing syndrome. The Klotho proteins (αKlotho and βKlotho) are essential components of endocrine fibroblast growth factor receptor (FGFR) complexes, as they are required for the high-affinity binding of FGF19, FGF21 and FGF23 to their cognate FGFRs. Alpha-Klotho is predominantly expressed in the distal convoluted tubules of the kidneys whereas βKlotho is located in fat tissue and the liver.
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Congress Presentation
This Congress talk has been presented by Makoto Kuro-o during the 55th ERA-EDTA Congress in Copenhagen, Denmark.
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References
Read this selection of articles about the two summary report fields.
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New Editorial Board Member!
Francesco Trepiccione, Italy
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New ERA-EDTA Dialogues!
Strawberries always fill my heart with joy (...and my kidneys with potassium): a clinical case study
by Björn Meijers
Potassium intake in CKD patients. Are we prescribing too much? Or too little? What is your taking?
by Pietro Manuel Ferraro
Incremental dialysis: from (limited) evidence to daily practice
by Mariusz Kusztal
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Last weeks to comment these ERA-EDTA Dialogues!
A puzzling case for the transplantologist
by Ana Carina Ferreira
Therapeutic approach in multi-resistant FSGS: your opinion matters!
by Francesco Pesce
Is SGLT-2 inhibition being the dawn of a new era in preventing CKD progression in nondiabetic patients?
by Evangelia Ntounousi
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