 |
| Newsletter #8
(2), 2017 |
July 2017 |
| News |
|
As of June 2017 the number of members of our WG is stable at 393.
Activities of the WG during the 54th ERA-EDTA Congress in Madrid
have been the following:
| 1. |
CME course Implementation of the KDIGO update on CKD-MBD (attended by 328 people): |
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Part I |
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Chairs: Pieter Evenepoel, Leuven,
Belgium and Ziad Massy, Paris, France |
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Should the presence of vascular
calcification influence choice of phosphate binder? Jordi
Bover, Barcelona, Spain |
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Phosphate binder therapy in predialysis?
When and how? Adrian Covic, Iasi, Romania |
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- |
Current insights into dietary intervention
to modulate phosphate concentration and balance Vincent
Brandenburg, Aachen, Germany |
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Part II |
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Chairs: David Goldsmith, London,
United Kingdom Marc Vervloet, Amsterdam, The Netherlands
|
| |
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Screening for fracture risk in CKD Pablo
Antonio Ureña Torres, Saint-Ouen, France |
| |
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Position in CKD of novel compounds to treat
bone disease Sandro Mazzaferro, Rome, Italy |
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Any position left for active vitamin D?
Mario Cozzolino, Milan, Italy |
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Invited Lecture:
Update on CKD-MBD in Pediatrics Rukshana Shroff, London,
United Kingdom |
| 2. |
Joint Meeting of the CKD-MBD Board with the Japanese Society of Nephrology’s Delegation. Opened by the Presidents of the ERA-EDTA (Prof. Wiecek) and of the Japanese Society of Nephrology (Prof. Kashihara), this meeting testifies the progress of our collaboration with the JSN. Four young researchers, 2 from Europe and 2 from Japan, presented their original researches which were opened to discussion. The titles: |
| |
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Yosuke Nakagawa (Tokai University):
Relationship between Sclerostin, Bone metabolism Markers, and
Fracture in Hemodialysis Patients: Tokai Dialysis Cohort |
| |
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Dimitri Siriopol (Iasi University, Romania):
Association between MBD phenotypes and Mortality Risk: An
EuroDOPPS analysis |
| |
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Tatsufumi Oka (Osaka University) :
Proteinuria as A Risk Factor of Hypomagnesemia: The Most
Common Electrolyte Abnormality in Patients with Chronic Kidney
Disease |
| |
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Marc Vila Cuenca (Amsterdam, The Netherlands
and Barcelona, Spain): Active vitamin D protects endothelial
barrier disruption by CKD |
| |
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Brain storming on collaborative projects and
activities on CKD-MBD |
| 3. |
Calciphylaxis Registry: A Board Meeting was organized to adjourn on the number of Countries actively contributing to the registry. The critical points, mostly on the local EC rules, were discussed. Netherlands and Belgium could announce their progress, which is now expected to start case recordings. A first balance of recruitments is scheduled by the end of the year. |
| 4. |
EUROD Board Meeting. This was the first meeting of the board members that are not only nephrologists but also pathologists and endocrinologists. The EUROD initiative aims at revitalizing the bone biopsy policy in renal patients in Europe. Pieter Evenepoel, the promoter, detailed the attendees on the purpose and methods of this new project of the WG. Both incident and prevalent cases will be eligible for inclusion in a registry that is expected to increase our knowledge of bone disease in CKD. Contacts are underway with Companies possibly interested with the project for fund raising. |
|
| Current
and upcoming activities |
| Publications:
|
| 1. |
The second
paper in cooperation with the ERA-EDTA working group on
Renal Nutrition (ERN) on Vitamin D Status and its
Relationship to Muscle Health and Frailty in Chronic
Kidney Disease, has been published. Authored by Dr.
Pablo Molina, is available on the web (Molina
P, Carrero JJ, Bover J, Chauveau P, Mazzaferro
S, Torres PU; European Renal Nutrition (ERN) and Chronic
Kidney Disease-Mineral and Bone Disorder (CKD-MBD)
Working Groups of the European Renal
Association-European Dialysis Transplant Association
(ERA-EDTA) Vitamin D, a modulator of
musculoskeletal health in chronic kidney disease. J
Cachexia Sarcopenia Muscle. 2017 Jul 3. doi:
10.1002/jcsm.12218. [Epub ahead of print] Review.
PMID: 28675610 |
| 2. |
Based on the results of
a questionnaire on the subject among European
nephrologists, the paper by Pieter Evenepoel on clinical
practice in Europe related to bone biopsy policies in
CKD, , has been published on NDT (Evenepoel
P, D'Haese P, Bacchetta J, Cannata-Andia J,
Ferreira A, Haarhaus M, Mazzaferro S, Lafage Proust MH,
Salam S, Spasovski G, Cozzolino M; ERA-EDTA Working
Group on CKD-MBD. Bone biopsy practice patterns across
Europe: the European renal osteodystrophy initiative-a
position paper. Nephrol Dial Transplant. 2017 Mar 3.
doi: 10.1093/ndt/gfw468. [Epub ahead of print] PMID:
28339949). |
| 3. |
The CKD-MBD working
group intends to critically review the recently
published update in the KDIGO guideline on CKD-MBD. If
needed, the working group will take initiative to
comment on this update, and share its position in a
commentary. | |
| Cooperation: |
The CKD-MBD working group is
cooperating with:
| - |
The European
Society of Pediatric Nephrology in order to develop
common specific lines of clinical research in the field
of CKD-MBD, spanning both pediatric and adult
nephrology. Two papers have been recently published in
collaboration:
| 1. |
Rukshana Shroff
Mandy Wan Evi V. Nagler Sevcan
Bakkaloğlu Mario Cozzolino Justine
Bacchetta Alberto Edefonti
Constantinos J. Stefanidis Johan Vande Walle
Gema Ariceta Günter Klaus Dieter
Haffner Claus Peter Schmitt on behalf of the
European Society for Paediatric Nephrology
Chronic Kidney Disease Mineral and Bone
Disorders and Dialysis Working Groups.
Clinical practice recommendations for
treatment with active vitamin D analogues in
children with chronic kidney disease Stages
2–5 and on dialysis. Nephrol Dial Transplant
(2017) 32 (7): 1114-1127 (https://doi.org/10.1093/ndt/gfx080).
|
| 2. |
Rukshana Shroff Mandy
Wan Evi V. Nagler Sevcan
Bakkaloğlu Dagmar-C. Fischer Nicholas
Bishop Mario Cozzolino Justine
Bacchetta Alberto Edefonti Constantinos J.
Stefanidis Johan Vande Walle
Dieter Haffner Günter Klaus Claus Peter
Schmitt on behalf of the European Society
for Paediatric Nephrology Chronic Kidney
Disease Mineral and Bone Disorders and Dialysis
Working Groups. Clinical practice
recommendations for native vitamin D therapy in
children with chronic kidney disease Stages
2–5 and on dialysis. Nephrol Dial Transplant
(2017) 32 (7): 1098-1113. (https://doi.org/10.1093/ndt/gfx065) |
|
| - |
The Japanese Society of
Nephrology, (JSN) by being represented at each other
meetings, share continental experience and share
education. In addition, the working group will offer
all support to the JSN if needed in its intention to
establish their own MBD group, and is looking forward to
intensify cooperation and to bundle forces. |
| - |
The European Renal
Nutrition (ERN) working group in combining expertise on
scientific topics at the boundaries of MBD and the
nutritional impact on
that. |
|
| WG
Activities: |
| A |
Calciphylaxis
registry. The Internet site ( http://www.calciphylaxis.net/) is
now available in several languages for local uses.
Italy, Netherlands and Belgium can now recruit
patients. |
| B |
EUROD. the
European Renal OsteoDystrophy network is now
well defined. Besides board members meetings a CME
Congress will hopefully be organized in 2018. Also,
during 2018 the active collection of bone samples is
expected to start.
|
| C |
MBD contribution to
clinical endpoints in CKD. Dr. Vervloet and Massy
are guiding an ongoing evaluation on data from the
large EuroDOPPS registry to identify MBD phenotypes
with the highest risk for clinically relevant endpoints.
| | |
| Scheduled
activities |
| A |
The next CME initiative of the group,
is entitled “The Parathyroid Hormone (PTH) Day
in Chronic Kidney Disease. From Bench to Bedside.
Organized by Ziad MASSY, Martine Cohen-Solal, and Pablo
Urena, is scheduled in Paris, September 8th, 2017 at the
Hotel Pullman Paris Eiffel Tower, 18 avenue de Suffren – Paris.
Importantly, in this CME also the best original
contributions from young European investigators will be
presented orally. The Final Program is the
following: |
| |
09.00-09.15 Introduction: Ziad MASSY,
Martine COHEN-SOLAL and Pablo URENA-TORRES
09.15-11.00
Session 1
Lessons from basic
science, Parathyroid glands, molecules, and receptors,
FGF23/Klotho
Moderators: Jordi BOVER
(Spain) and Marc VERVLOET (The Netherlands)
09.15-09.40 1- Parathyroid glands in CKD: anatomy,
histology, physiology and molecular biology
in CKD (monoclonality): (Tilman DRUEKE, France)
09.40-10.05 2- Parathyroid glands localization in CKD:
Ultrasounds, Scintigraphies, MRI, PET
(Elif
HINDIE, France)
10.05-10.30 3-
Calcium-sensing and PTH receptor in CKD (Ziad MASSY,
France)
10.30-10.55 4- PTH regulation by the
Klotho/FGF23 axis in CKD (Mario COZZOLINO,
Italy)
BREAK
11.15-12.55 Session 2
Diagnostic
issues and PTH as a prognostic
biomarker
Moderators: Martine
COHEN-SOLAL (France) and Dominique PRIE (France)
11.15-11.40 5- Effect of PTH, PTHrP and their
fragments in the central nervous system (Franck OURY,
France)
11.40-12.05 6- PTH measurement in
CKD subjects (Etienne CAVALIER, Belgium)
12.05-12.30 7- Relation between PTH and biochemical markers
of MBD (Junichiro James KAZAMA, Japan)
12.30-12.55 8-
Deleterious effects of PTH on the heart (Vincent BRANDENBURG,
Germany)
12.55-14.00 LUNCH
14.00-15.40 Session 3
How
to treat secondary hyperparathyroidism anno
2017
Moderators: David GOLDSMITH
(UK) and Sandro MAZZAFERRO (Italy)
14.00-14.25 9-
Control of secondary hyperparathyroidism by old and new
vitamin D compounds
(Stuart SPRAGUE, USA)
14.25-14.50
10- Old and new calcimimetics (João FRAZAO, Portugal)
14.50-15.15 11- Is there any indication for parathyroidectomy
in 2017 (Adrian COVIC, Romania)
15.15-15.40 12-
Persistent high PTH after kidney transplantation (Pieter
EVENEPOEL, Belgium)
BREAK
16.00-16.30
Session 4
Presentation of The Three Best
Posters
Moderators: Pablo
URENA-TORRES (France) and Ziad MASSY (France)
16.00-16.10: Poster 1 16.10-16.20 Poster 2 16.20-16.30 Poster
3
16.30-17.30 Session
5
Back to practice:
clinical cases: what would you
do?
Moderators: Pieter EVENEPOEL
(Belgium) + all faculty members
16.30-17.00: 13- A
clinical case of high PTH (Marc VERVLOET, The Netherlands)
17.00-17.30: 14- A clinical case of low PTH (Sandro
MAZZAFERRO, Italy)
17.30-17.45 Conclusions and perspectives
(Ziad MASSY and Pablo URENA) |
| |
Travel Grant opportunities available for young investigators.
For more information ask: ckd-mbd@era-edta.org |
|
| CKD-MBD
related publications in NDT and CKJ |
| http://www.era-edta.org/ckdmbd/NEWSLETTER_8_2.pdf |
As a contribution of ERA-EDTA
communication team, we are again reporting on the most recent papers
published on the journals of our society and dealing with CKD-MBD.
The content of this group of papers is reported in a separate link
|
Clinical Kidney Journal
(CKJ) The possibility of
submitting papers to CKJ free of charge submission fees,
continues up to the end of the year! Run to
submit original
papers! | | |