CKD-MBD
Newsletter #7 (1), 2017
January 2017
News

As of December 2016 the number of members of our WG is 380.

The WG Board Members met in Amsterdam, on September 23rd, just before the CME Symposium, just to update on the renewal of the board members which is expected by January 2017.

The Amsterdam meeting on “Bone in CKD" was a success with 102 registered attendants from Europe. During this day a wide range of topics were covered related to renal osteodystrophy, presented by experts in the field. In addition, during meet-the-experts session, in interactive format difficult cases were discussed moderated by practicing clinicians, assisting in translating novel data from research to clinical practice. Most lively discussions also followed the oral presentations by young researchers. This highly appreciated session exemplified the pan-European interest in CKD-MBD. The final program is available at: http://era-edta.org/ckdmbd/Final_symposium_amsterdam.pdf . Notably, in this meeting non-nephrologists experts, like endocrinologists and reumatologists shared their clinical and experimental experience on the issues of bone histology, research and evaluation of fracture risk and interpretation of DXA in renal patients. Since CKD-MBD borders with these specialists their input had high educational value, also for experienced nephrologists. Further, as one important step of collaboration of ERA-EDTA with the Japanese Society of Nephrology, the topic of uremic toxicity on bone was presented by Professor. Masafumi Fugakawa, former President of JSN. Currently a special issue of the Journal of Nephrology is in preparation with contributions of all presenting authors..

The official meeting of the WG Board Members was held in Rome at Fiumicino Airport, on December 20th , 2016. According to the WG rules that impose renewal of the board members by January 2017, two components, Professors Jordi Bover and Vincent Brandenburg, had to leave. Both are co-founders and have been motors of the WG activities. Their role in the growth of the WG was outstanding and all members declared ample gratitude for the excellent job done. Their link with the WG will however continue as responsible of the website for Professor Bover and as promoter of the European Calciphylaxis Network for Professor Brandenburg.
The new member of the board, Professor Joao Frazao from Portugal, attended the meeting for the first time and was welcomed from all the board members.
A representative of the ERA-EDTA office, Valentina Cocchi, attended the meeting to inform that a general Secretary Office for all ERA-EDTA WGs was recently created and that she will be on charge as Chief Secretary.

Current and upcoming activities
Publications:
1. The review paper, partly narrative and partly systematic written in collaboration with Cochrane Group, on the role of Magnesium in renal patients has been recently published on Magnesium Research.Link at:
https://www.ncbi.nlm.nih.gov/pubmed/28007671
2. The first scheduled paper written in cooperation with the ERA-EDTA working group on Renal Nutrition (ERN) and Authored by Dr. Marc Vervloet, has been successfully published on Nature reviews in Nephrology. The link is:
https://www.ncbi.nlm.nih.gov/pubmed/27867189
3. A second paper in cooperation with the ERA-EDTA working group on Renal Nutrition (ERN) on Vitamin D Status and its Relationship to Muscle Health and Frailty in Chronic Kidney Disease, Authored by Dr. Pablo Molina, is now complete and under review
4. The book Edited by Urena, Cozzolino and Vervloet “Vitamin D in Chronic Kidney Disease” (Springer) is now available at:
http://www.springer.com/us/book/9783319325057
5. A review paper is in press in our Society's journal Nephrology, Dialysis and Transplantation by professor Pieter Evenepoel on clinical practice in Europe related to bone biopsy in CKD based on the results of a recent questionnaire on the subject among European nephrologists.
6. The CKD-MBD working group intends to critically review the upcoming update in the KDIGO guideline on CKD-MBD. If needed, the working group will take initiative to comment on this update, and share its position in a commentary.
Cooperation: The CKD-MBD working group is cooperating with:
- The European Society of Pediatric Nephrology in order to develop common specific lines of clinical research in the field of CKD-MBD, spanning both pediatric and adult nephrology.
- The Japanese Society of Nephrology, (JSN) by being represented at each other meetings, share continental experience and share education. In addition, the working group will offer all support to the JSN if needed in its intention to establish their own MBD group, and is looking forward to intensify cooperation and to bundle forces.
- The European Renal Nutrition (ERN) working group in combining expertise on scientific topics at the boundaries of MBD and the nutritional impact on that.

WG Activities:
A
Calciphylaxis registry. The Internet site (http://www.calciphylaxis.net) is now available in several languages for local uses. Approval from local ECs came first from Italy and the first three cases were recruited into the registry.
B EUROD. The European Renal OsteoDystrophy network aims at joining nephrologists, endocrinologists and pathologists with all relevant expertises in renal osteodystrophy (Coordinator: Professor Evenepoel). It's aim is the foundation of a bone biopsy registry, to promote scientific interest in the field, provide education and in the future to establsih a large biobank of patients undergoing bone biopsy, in order to improve knowledge on the role of bone in systemic disease.
C MBD risk prediction score in CKD. Dr. Vervloet and Massy are aiming at evaluating data from large registries to develop a score capable of predicting risk attributable to MBD. The analysis will be performed on the EuroDOPPS data set.
Next appointments
A
The CME course of our WG, for the next ERA-EDTA congress in Madrid, June 3rd, 2017 will have the following title:
Implementation of the KDIGO update on CKD-MBD
CKD-MBD (Working Group on Chronic Kidney Disease - Mineral and Bone Disorders):
  Part I
Should the presence of vascular calcification influence choice of phosphate binder?
Speaker to be confirmed
Phosphate binder therapy in predialysis? When and how?
Adrian Covic, Iasi, Romania
Current insights into dietary intervention to modulate phosphate concentration and balance
Vincent Brandenburg, Aachen, Germany
  Part II
Screening for fracture risk in CKD
Pablo Antonio Ureña Torres, Saint-Ouen, France
Position in CKD of novel compounds to treat bone disease
Sandro Mazzaferro, Rome, Italy
Any position left for active vitamin D?
Mario Cozzolino, Milan, Italy
Invited lecture:
Update on CKD-MBD in Pediatrics
Rukshana Shroff, London, United Kingdom
(See more at: http://www.era-edta2017.org/en-US/preliminary-scientific-programme-1#sthash.4JWqkreE.dpuf)
B
Organized by Ziad Massy, Martine Cohen-Solal, and Pablo Urena, a further CME Meeting is also scheduled in Paris, on September 8th, 2017, with the following title: The Parathyroid Hormone (PTH) Day in chronic kidney disease (CKD). From Bench to Bedside.
The venue will be the Amphitheater Villemin at University Paris-Diderot, Paris 7. 10 Avenue de Verdun 75010 Paris. The preliminary program is the following:
 
Session 1 de 09h15-11h00: Lessons from basic science, Parathyroid glands, molecules, and receptors, FGF23/Klotho
Moderators: Jordi BOVER and Marc VERVLOET
  09h15-09h40: 1- Parathyroid glands in CKD: anatomy, histology, physiology and molecular biology in CKD (monoclonality): (Tilman DRUEKE, France)
  09h40-10h05: 2- Calcium-sensing and PTH receptor in CKD (Ziad MASSY, France)
  10h05-10h30: 3- PTH regulation by the Klotho/FGF23 axis in CKD (Mario COZZOLINO, Italy)
  10h30-10h55: 4- Effect of PTH, PTHrP and their fragments in the central nervous system (Franck OURY, France)
 
BREAK (20 minutes)
 
Session 2 de 11h15-12h40: Diagnostic issues and PTH as a prognostic biomarker
Moderators: Martine COHEN-SOLAL (France) and Dominique PRIE (France)
  11h15-11h35: 5- Parathyroid glands localization in CKD: Ultrasounds, Scintigraphies, MRI, PET (Elif HINDIE, France)
  11h35-11h55: 6- PTH measurement in CKD subjects (Etienne CAVALIER, Belgium)
  11h55-12h15: 7- Relation between PTH and biochemical markers of MBD (Pablo URENA, France)
  12h15-12h40: 8- Deleterious effects of PTH on the heart (Vincent BRANDENBURG, Germany)
 
LUNCH (12h40-14h00)
 
Session 3 de 14h00-15h40: How to treat secondary hyperparathyroidism anno 2017
Moderators: David GOLDSMITH (England) and Sandro MAZZAFERRO (Italy)
  14h00-14h25: 9- Control of secondary hyperparathyroidism by old and new vitamin D compounds (Pr Stuart Sprague)
  14h25-14h50: 10- Old and new calcimimetics (João Frazao, Portugal)
  14h50-15h15: 11- Is there any indication for parathyroidectomy in 2017 (A. COVIC, Romania)
  15h15-15h40: 12- Persistent high PTH after kidney transplantation (Pieter EVENEPOEL, Belgium)
 
BREAK (20 minutes)
 
Session 4 de 16h00-16h30: Presentation of The Three Best Posters
Moderators: Pablo URENA and Ziad MASSY
 
16h00-16h10: Poster 1     16h10-16h20: Poster 2     16h20-16h30: Poster 3
 
Session 5 de 16h30-17h30: Back to practice: clinical cases: what would you do?
Moderators: Pieter EVENEPOEL + all faculty members
  16h00-16h30: 13- A clinical case of high PTH (Marc VERVLOET, Netherland)
  16h30-17h00: 14- A clinical case of low PTH (Sandro MAZZAFERRO)
     
  17h00-17h15: Conclusions and perspectives (Ziad MASSY and Pablo URENA)
CKD-MBD related publications in NDT and CKJ
http://www.era-edta.org/ckdmbd/NEWSLETTER_7_1_2017.pdf
As a contribution of ERA-EDTA communication team, we are again reporting on the most recent papers published on the journals of our society and dealing with CKD-MBD. The content of this third group of papers is reported in a separate link
Clinical Kidney Journal (CKJ)
The possibility of submitting papers to CKJ free of charge submission fees,
continues up to the end of the year! Run to submit original papers!