RENAL FAILURE, DYSPNOEA AND HAEMOPTYSIS

by Michal Chmielewski

Department of Nephrology, Transplantology and Internal Medicine, Medical University of Gdansk

Corresponding author:

Michal Chmielewski

Download short CV of the first author (Michal Chmielewski) CV Michal Chmielewski



CASE VIGNETTE:
A 31 year old patient was admitted due to dyspnoea, haemoptysis, fever, anuria and severe hypertension, which started two days prior to hospitalization. Up to this day he felt perfectly healthy. On admission he was in severe condition with dyspnoea, overhydration and leg oedema. His blood pressure was 210/100 mmHg, heart rate 96/min, on auscultation he presented bilateral cracles and wheezes. His chest x-ray presented below, showed features of pulmonary oedema.



His lab results included: creatinine 19 mg/dl (please present also in µmol/l) , BUN 120 mg/dl, K 6.1 mmol/l, Hb 7.9 g/dl, PLT (please explain= 265 G/l, WBC 11.4 G/l, CRP 210 mg/l. Being anuric and having pulmonary oedema, he was immediately dialysed. Due to the suspicion of pneumonia (haemoptysis, fever, leukocytosis, high CRP), he was administered ceftazidime and azythromycin. The following day he underwent a chest CT, in which alveolar haemorrhage was described.


  • Question 1) - Since the patient presented classical features of Goodpasture syndrome (renal failure, dyspnoea, haemoptysis), blood was taken for the presence of antibodies:
    (Only ONE answer is correct)

  • a) against proteinase 3.
  • b) against GBM.
  • c) against double-stranded DNA.
  • d) against myeloperoxidase.