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FOR KIDNEY & BLOOD
PRESSURE RELATED
DISORDERS

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An official publication of

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NDT-Educational@ENP Newsletter

Issue 3 - March 2019

EDITOR IN CHIEF: Davide Bolignano

EDITORIAL BOARD: click here for the complete list

NEWSLETTER DESIGN: Francesca Trebelli

Summary Reports from 55th ERA-EDTA Congress

Inflammation in crystal nephropathies

Presented by Hans-Joachim Anders

Summary1

Deposits of crystals, misfolded proteins, or airborne nanoparticles or microparticles can cause diverse acute or chronic organ injuries. Crystal-associated diseases, although with diverse clinical presentations, share several molecular and cellular pathomechanisms, and are usually referred to as the ‘crystallopathies’.

According to their predominant pathologic mechanism, Mulay and Anders suggested a classification of crystal-related or microparticle-related disorders in the three categories: 1) acute necroinflammation, 2) chronic tissue remodeling leading to tissue atrophy and scarring, and 3) obstruction of ducts, cavities, or vessels by large crystal masses, calculi, or stones.

Congress Presentation

This Congress talk has been presented by Hans-Joachim Anders during the 55th ERA-EDTA Congress in Copenhagen, Denmark.

Jayne

Klotho and endocrine FGFs – marker of CKD progression and cardiovascular complications?

Presented by Makoto Kuro-o

Summary2

Klotho, the Greek goddess who spins the thread of life, has become popular among nephrologists, as the genes named after her encode co-receptors for hormones that play critical roles in the pathophysiology of chronic kidney disease (CKD).

The Klotho gene was discovered in 1997 when mice with serendipitous silencing of this gene developed premature ageing syndrome. The Klotho proteins (αKlotho and βKlotho) are essential components of endocrine fibroblast growth factor receptor (FGFR) complexes, as they are required for the high-affinity binding of FGF19, FGF21 and FGF23 to their cognate FGFRs. Alpha-Klotho is predominantly expressed in the distal convoluted tubules of the kidneys whereas βKlotho is located in fat tissue and the liver.

   Congress Presentation

This Congress talk has been presented by Makoto Kuro-o during the 55th ERA-EDTA Congress in Copenhagen, Denmark.

Wanner

References

Read this selection of articles about the two summary report fields.

Journals

New Editorial Board Member!

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Francesco Trepiccione, Italy

New ERA-EDTA Dialogues!

Dialogue

Strawberries always fill my heart with joy (...and my kidneys with potassium): a clinical case study

by Björn Meijers

Potassium intake in CKD patients. Are we prescribing too much? Or too little? What is your taking?

by Pietro Manuel Ferraro

Dialogue
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Incremental dialysis: from (limited) evidence to daily practice

by Mariusz Kusztal

 Last weeks to comment these ERA-EDTA Dialogues!

Dialogue

A puzzling case for the transplantologist

by Ana Carina Ferreira

Therapeutic approach in multi-resistant FSGS: your opinion matters!

by Francesco Pesce

Dialogue
Dialogue

Is SGLT-2 inhibition being the dawn of a new era in preventing CKD progression in nondiabetic patients?

by Evangelia Ntounousi

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