Professor of Medicine and Head
Department Internal Medicine IV
– Renal and Hypertensive Disease –
Saarland University Medical Centre
Kirrberger Straße
66421 Homburg/Saar
Germany
Tel.: 06841– 16 23 526
Fax: 08641 – 16 23 540
Email: indfli@uks.eu

Research Fellow at the Division of Nephrology, Department of Internal Medicine, Ruperto-Carola University, Heidelberg (Germany)

Coordinator of the clinical research program at the Division of Nephrology, Ruperto-Carola University, Heidelberg (Germany)

Research Fellow at the Department of Endocrinology and Metabolism, University of Virginia, Charlottesville (USA)

Faculty Rank in Internal Medicine on "Relationship between the Renin-Angiotensin-System, Calcium-regulating Hormones and Insulin"

Assistant Professor (Internal Medicine) at the Ruperto-Carola University, Heidelberg (Germany)

Professor of Medicine and Head
Department Internal Medicine IV - Renal and Hypertensive Disease - University Medical Centre Homburg/Saar (Germany)

BOARD CERTIFICATIONS

1996

Board certification in Nephrology

Bernd Tersteegen Prize

American Society of Nephrology (ASN)

European Dialysis and Transplant Association (EDTA)

European Study Group on Insulin Resistance (EGIR)

European Study Group on Uremia Toxicity

German Society of Internal Medicine (DGIM)

German Society of Nephrology (GfN)

International Society of Nephrology (ISN)

Working Group on Pathogenesis of Atherosclerosis of the European Society of Cardiology

MEMBER OF THE "EDITORIAL BOARD"

Der Nephrologe

Clinical Nephrology (CN)

Journal of the American Society of Nephrology (JASN)

Néphrologie & Thérapeutique (German guest editor)

American Journal of Hypertension (AJH)

Key original publications of the last 3 years [2005 - 2007]

Schiffer M, Tossidou I, Bartels J, Park JK, Menne J, Hertel B, Fliser D.
Erythropoietin-analoga as podocyte protective agents in diabetic nephropathy.
(submitted)

Faulhaber-Walter R, Hafer C, Jahr N, Vahlbruch J, Hoy L, Haller H, Fliser D, Kielstein J.
The Hannover-Dialysis-Outcome (HAND-OUT)-study: Comparison of conventional versus intensified extended daily dialysis in treatment of patients with acute renal failure on the intensive-care unit.
(submitted)

Zürbig P, Coon JC, Frommberger M, Fliser D, Ganser A, Girolami MA, Haubitz M, Kellmann M, Kliem V, Kolch W, Melter M, Neusüss C, Novak J, Ross M, Rossing K, Schanstra J, Semjonow A, Theodorescu D, Mischak H, Schmitt-Kopplin P.
A proteome library of urine peptides for disease diagnosis.
PLOS Medicine (in revision)

David S, Kümpers P, Seidler V, Haller H, Fliser D.
The use of N-terminal pro b-type natriuretic peptide (NT pro-BNP) to asses left ventricular dysfunction and postdialytic volume status in haemodialysis patients.
Nephrol Dial Transplant 2008; in press

De Groot K, Kuklik K, Broecker V, Schwarz A, Gwinner W, Kreipe H, Haller H, Fliser D, Mengel M.
Toll-like 2 receptor and renal allograft function.
Am J Nephrol 2008; in press

Menne J, Park JK, Shushakova N, Mengel M, Bahlmann F, Meier M, Haller H, Fliser D.
Continuous erythropoietin receptor activation affects different pathways of diabetic renal injury.
J Am Soc Nephrol 2007; 18: 2046-2053

Fliser D, Kollerits B, Neyer U, Lhotta K, Ritz E, Kronenberg F.
Calcium-phosphate metabolism, FGF-23 and progression of chronic kidney disease: The Mild to Moderate Kidney Disease (MMKD) Study.
J Am Soc Nephrol 2007; 18: 2600-2608

Fliser D, Kolleritz B, Heid IM, Ritz E, Kronenberg F; for the MMKD Study Group.
Gender-specific association of adiponectin as a predictor of progression of chronic kidney disease: The Mild to Moderate Kidney Disease Study.
Kidney Int 2007; 71: 1279-1286

Sorrentino SA, Bahlmann FH, Besler C, Müller M, Schulz S, Kirchhoff N, Dörries C, Fliser D, Haller H, Drexler H, Landmesser U.
Peroxisome proliferator-activated receptor-gama activation with rosiglitazone restores impaired in vivo re-endothelialization capacity of endothelial progenitor cells in type II diabetics.
Circulation 2007; 116: 163-173

Spanaus KS, Kronenberg F, Ritz E, Schlapbach R, Fliser D, Hersberger M, Kollerits B, Konig P, von Eckardstein A; for the MMKD Study Group.
B-Type natriuretic peptide concentrations predict the progression of nondiabetic chronic kidney disease: The Mild-to-Moderate Kidney Disease Study.
Clin Chem2007; 53: 1264-12-72

De Groot K, Goldberg C, Bahlmann FH,Woywodt A, Haller H, Fliser D, Haubitz M.
Circulating endothelial progenitor cells (EPCs) in the course of ANCA-associated vasculitis.
Arthritis Rheum 2007; 56: 3847-3853

Gueler F, Park JK, Rong S, Kirsch T, Lindschau C, Zheng W, Elger M, Menne J, Fiebeler A, Fliser D, Luft FC, Haller H.
Statins attenuate ischemia reperfusion injury in rat kidneys via induction of heme oxygenase-1 in infiltrating macrophages.
Am J Pathol2007; 170: 1192-1199

Menne J, Agrawal R, Park JK, Lindschau C, Kielstein JT, Kirsch T, Marx A, Muller D, Bahlmann FH, Bode-Boger SM, Haller H, Fliser D.
Cellular and molecular mechanisms of tissue protection by lipophilic calcium channel blockers.
FASEB J 2006; 20: 994-996

Kielstein JT, Donnerstag F, Gasper S, Menne J, Kielstein A, Bode-Boger SM, Fliser D.
ADMA increases arterial stiffness and decreases cerebral blood flow in humans.
Stroke 2006; 37: 2024-2029

Rifai K, Ernst T, Kretschmer U, Haller H, Manns MP, Fliser D. Removal selectivity of Prometheus: Anew extracorporeal liver support device. World J Gastroenterol 2006; 12: 940-944

Kielstein JT, Salpeter SR, Bode-Boeger SM, Cooke JP, Fliser D.
Symmetric dimethylarginine (SDMA) as endogenous marker of renal function – a meta-analysis.
Nephrol Dial Transplant 2006; 21: 2446-2451

Rifai K, Hafer C, Rosenau J, Athmann C, Haller H, Manns MP, Fliser D.
Treatment of severe refractory pruritus with fractionated plasma separation and adsorption (PROMETHEUS).
Scand J Gastroenterol 2006; 41:1212-1217

Boes E, Fliser D, Ritz E, Kraatz G, Lhotta K, Mann JFE, Müller GA, Neyer U, Riegel W, Riegler P, Kronenberg F.
Apolipoprotein A-IV predicts progression of chronic kidney disease: The Mild to Moderate Kidney Disease (MMKD) Study.
J Am Soc Nephrol 2006; 17: 528-536

Czock D, Hüsig-Linde C, Langhoff A, Schoepke T, Hafer C, de Groot K, Swoboda S, Kuse E, Fliser D, Keller F, Kielstein JT.
Moxifloxacin and levofloxacin in intensive care unit patients with acute renal failure undergoing extended dialysis.
C J Am Soc Nephrol 2006; 1: 1263-1268

Fliser D, Wagner KK, Loos A, Tsikas D, Haller H.
Chronic angiotensin II subtype 1-receptor inhibition reduces (intra)renal vascular resistance in patients with type 2 diabetes mellitus.
J Am Soc Nephrol 2005; 16: 1135-1140

Becker B, Kronenberg F, Kielstein JT, Haller H, Morath C, Ritz E, Fliser D.
Renal insulin resistance syndrome, adiponectin and cardiovascular events in patients with kidney diseases: The Mild to Moderate Kidney Disease (MMKD) Study.
J Am Soc Nephrol 2005; 16: 1091-1098

Fliser D, Kronenberg F, Kielstein JT, Morath C, Bode-Boger SM, Haller H, Ritz E.
Asymmetric dimethylarginine (ADMA) and progression of chronic kidney disease: The Mild to Moderate Kidney Disease (MMKD) Study.
J Am Soc Nephrol 2005; 16: 2456-2461

Bahlmann F, De Groot K, Mueller O, Hertel B, Haller H, Fliser D.
Stimulation of endothelial precursor cells: a new putative therapeutic effect of angiotensin II receptor antagonists.
Hypertension 2005: 45: 526-529

De Groot K, Bahlmann FH, Bahlmann E, Menne J, Haller H, Fliser D.
Kidney graft function determines endothelial progenitor cell number in renal transplant recipients.
Transplantation 2005; 79: 941-945

Rifai K, Haller H, Manns MP, Fliser D.
The Prometheus device for extracorporeal support of combined liver and renal failure.
Blood Purificat 2005; 23: 298-302

Gueler F, Gwinner W, Schiborr C, Kirsch T, Fiebeler A, Martin M, Haller H,  Fliser D.
Biocompatibility parameters of different dialysis membranes assessed during systemic inflammation.
Blood Purificat 2005; 23: 196-202

Landmesser U, Bahlmann FH, Mueller M, Spiekermann S, Kirchhoff N, Schulz S, de Groot K, Fliser D, Fauler G, März W, Drexler H.
Simvastatin vs. ezetimibe: pleiotropic vs. lipid lowering effects on endothelial function and endothelial progenitor cells in humans.
Circulation 2005: 111: 2356-2363

Kielstein JT, Bode-Boger SM, Hesse G, Gatzke R, Tacacs A, Fliser D, Hoeper MM.
Asymmetric dimethylarginine (ADMA), pulmonary hemodynamic indices, and survival in patients with primary pulmonary hypertension.
Arterioscler Thromb Vasc Biol 2005; 25: 1414-1418

Chalmers MJ, Mackay CL, Hendrickson CL, Wittke S, Walden M, Mischak H, Fliser D, Just I, Marshall AG.
Combined top-down and bottom-up mass spectrometric approach to characterization of biomarkers for renal disease.
Anal Chem 2005; 77: 7163-7171

Theodorescu D, Fliser D, Wittke S, Mischak H, Krebs R, Walden M, Eltze E, Bettendorf O, Wuelfing C, Semjonov A.
Capillary electrophoresis coupled to mass spectrometry as a tool to define prostate cancer biomarkers: a preliminary study.
Electrophoresis 2005; 27: 2797-2808

Meier M, Kaiser T, Herrmann A, Knuppel S, Hillmann M, Haller H, Fliser D, Mischak H.
Identification of urinary protein pattern in Type 1 diabetic adolescents with early diabetic nephropathy by a novel combined proteome analysis.
J Diabetes Complicat 2005; 19: 223-232